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Protein Misfolding Diseases: Current and Emerging Principles and TherapiesFrom Wiley
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An increasingly aging population will add to the number of individuals suffering from amyloid. Protein Misfolding Diseases provides a systematic overview of the current and emerging therapies for these types of protein misfolding diseases, including Alzheimer's, Parkinson's, and Mad Cow. The book emphasizes therapeutics in an amyloid disease context to help students, faculty, scientific researchers, and doctors working with protein misfolding diseases bridge the gap between basic science and pharmaceutical applications to protein misfolding disease.
- Sales Rank: #3824066 in Books
- Published on: 2010-06-28
- Original language: English
- Number of items: 1
- Dimensions: 9.50" h x 2.10" w x 6.60" l, 3.64 pounds
- Binding: Hardcover
- 1069 pages
Review
“The book is very well organized and clearly written, and contains a large number of nice figures and illustrations, some in color, which certainly help to simplify the complex thematic material. The contributions provide a sufficient body of background information, are concisely written, and contain many references, which make them valuable bibliographic sources.” (Angewandte Chemie, December 2010)
"In this valuable contribution to the understanding of protein- deposition diseases, Ramirez-Alvarado (biochemistry and molecular biology, Mayo Clinic College of Medicine) and international contributors to 45 chapters present an integrated approach to the process and consequences of protein aggregation." (Book News, September 2010)
From the Inside Flap
An in-depth look at new discoveries in protein misfolding disease research
Protein misfolding/aggregation diseases are a medical puzzle that has baffled researchers for many years. These diseases are characterized by the presence of protein deposits, or amyloid fibrils, which gather in the intracellular and/or extracellular spaces in a variety of tissues. Unchecked, the process of amyloidogenesis leads to proteotoxicity, cell loss, and eventually organ dysfunction, and causes such well-known and devastating diseases as Alzheimer's, Parkinson's, and Mad Cow.
Employing a diversity of research approaches, including chemical and biophysical, cellular, and animal models, the authors investigate various amyloid diseases and outline progress made in understanding them in this important book. Included are novel strategies to combat a wide variety of degenerative diseases. With a systematic overview, Protein Misfolding Diseases:
Emphasizes therapeutics in an amyloid disease context, which helps bridge the gap between basic science and pharmaceutical applications to protein misfolding diseases
Provides a comprehensive survey of many of the topics surrounding the universal biological aspects of protein misfolding
Includes a Foreword by R. John Ellis, International Gairdner Award Winner 2004
Is coedited by Jeffery W. Kelly and Christopher M. Dobson, leaders in the field of protein biochemistry
Protein Misfolding Diseases uses the latest medical data from expert scientists and protein misfolding clinicians to launch a multi-targeted assault on the process of amyloid fibril formation. Fresh insight into the etiology of these maladies helps researchers gain a thorough understanding of the bases of these diseases and offers guidance in designing therapeutic strategies to build on promising new findings--and bring hope one step closer to reality.
From the Back Cover
An in-depth look at new discoveries in protein misfolding disease research
Protein misfolding/aggregation diseases are a medical puzzle that has baffled researchers for many years. These diseases are characterized by the presence of protein deposits, or amyloid fibrils, which gather in the intracellular and/or extracellular spaces in a variety of tissues. Unchecked, the process of amyloidogenesis leads to proteotoxicity, cell loss, and eventually organ dysfunction, and causes such well-known and devastating diseases as Alzheimer's, Parkinson's, and Mad Cow.
Employing a diversity of research approaches, including chemical and biophysical, cellular, and animal models, the authors investigate various amyloid diseases and outline progress made in understanding them in this important book. Included are novel strategies to combat a wide variety of degenerative diseases. With a systematic overview, Protein Misfolding Diseases:
-
Emphasizes therapeutics in an amyloid disease context, which helps bridge the gap between basic science and pharmaceutical applications to protein misfolding diseases
-
Provides a comprehensive survey of many of the topics surrounding the universal biological aspects of protein misfolding
-
Includes a Foreword by R. John Ellis, International Gairdner Award Winner 2004
-
Is coedited by Jeffery W. Kelly and Christopher M. Dobson, leaders in the field of protein biochemistry
Protein Misfolding Diseases uses the latest medical data from expert scientists and protein misfolding clinicians to launch a multi-targeted assault on the process of amyloid fibril formation. Fresh insight into the etiology of these maladies helps researchers gain a thorough understanding of the bases of these diseases and offers guidance in designing therapeutic strategies to build on promising new findings—and bring hope one step closer to reality.
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